J. C. de la Torre, Ph.D.
This content is PDF only. Please click on the PDF icon to access.
The possibility that dimethyl sulfoxide (DMSO) may facilitate the transport of other drug molecules across the blood-brain barrier (bbb) was studied using 3, 4-dihydroxyphenylalanine (L-DOPA) and 5-hydroxytryptophan (5-HTP). These two amino acids are the direct precursors of dopamine and serotonin respectively.
Male Sprague-Dawley rats were injected with a solution containing 75 mg/kg of L-DOPA and 750 mg/kg of DMSO. A second group of animals were injected with a similar solution containing 100 mg/kg of 5-HTP and 750 mg/kg of DMSO. Control animals received the same doses of L-DOPA and 5-HTP preceded by the dopa decarboxylase inhibitor (DCI) Ro 4-4602. All
de la Torre JC. The Blood-Brain Barrier for Monoamine Precursors After DMSO.. Ann Intern Med. 1970;72:806. doi: https://doi.org/10.7326/0003-4819-72-5-806_3
Download citation file:
Published: Ann Intern Med. 1970;72(5):806.
Copyright © 2020 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use