Mark C. Levine, M.D., (Associate); Jack R. Grommons, M.D.
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An unusual disorder of unknown cause, characterized by continuous muscle fasciculation and myotonia in otherwise normal young men, was first described by Isaacs in 1961; a total of five cases have been reported. Other than electromyographic evidence of continuous motor unit firing, all biochemical and neurodiagnostic studies have been normal, and symptoms have responded dramatically to therapy with diphenylhydantoin.
A patient with a similar clinical picture whose muscular twitchings and stiffness have been controlled by diphenylhydantoin for over 5 years is presented. Extensive investigations (including serum electrolytes, calcium, magnesium, enzymes, cholinesterase, muscle biopsy, cerebrospinal fluid analysis, electroencephalogram, and X rays)
Levine MC, Grommons JR. The Syndrome of Continuous Muscle Fiber Activity.. Ann Intern Med. 1970;72:807. doi: https://doi.org/10.7326/0003-4819-72-5-807_3
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Published: Ann Intern Med. 1970;72(5):807.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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