Kenneth M. Moser, M.D., F.A.C.P.; Michel Guisan, M.D.; William L. Ashburn, M.D.
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In the past, defects observed in pulmonary perfusion scintiphotography often have been equated with the diagnosis of pulmonary embolism. In fact, such defects lack diagnostic specificity since many other disease processes can alter regional lung blood flow and produce such defects. Physiologic-anatomic considerations suggested that specificity might be gained by combining ventilation with perfusion radionuclide studies. This possibility has been explored in a large series of patients with known or suspected pulmonary disease.
Distribution of pulmonary blood flow was determined by intravenous injection of 133Xenon-in-saline or 131Iodine-labelled albumen macroaggregates. Distribution of ventilation was determined by inhalation of 133Xenon gas. A
Moser KM, Guisan M, Ashburn WL. Differentiation of Pulmonary Vascular from Parenchymal Diseases by Ventilation/Perfusion Scinitiphotography.. Ann Intern Med. 1970;72:808. doi: https://doi.org/10.7326/0003-4819-72-5-808_2
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Published: Ann Intern Med. 1970;72(5):808.
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