Jack Lieberman, M.D., F.A.C.P.; Charles Mittman, M.D.
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Detection of the carrier state for alpha1-antitrypsin deficiency is valuable for studying the genetic predisposition to chronic obstructive lung disease and as a screening test in preventive medicine. Sera are screened for antitrypsin deficiency by protein electrophoresis on cellulose-acetate membranes followed by an enzymatic assay of inhibitor when the alpha1-globulin is less than 0.2 g%. However, the detection of heterozygotes may conceivably be impaired when other serum protein abnormalities exist or when the antitrypsin level has risen into the low normal range during an acute illness. A survey of patients without obstructive lung disease at the City of Hope Medical
Lieberman J, Mittman C. Aids in Screening for Heterozygous Alpha1-Antitrypsin Deficiency.. Ann Intern Med. 1970;72:809. doi: https://doi.org/10.7326/0003-4819-72-5-809_3
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Published: Ann Intern Med. 1970;72(5):809.
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