John Barsch, M.D.; Charles Birbara, M.D.; G. W. N. Eggers Jr., M.D.; Frank Krumlofsky, M.D.; Y. W. Sanit, M.D.; Wilfred Smith, M.D.; Roy Smith, M.D.; James Webster, M.D., F.A.C.P.
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Prolonged artificial ventilation with high oxygen concentration is known on occasion to cause lethal lung damage. The lungs show vascular injury, hyaline membranes, atelectasis, interstitial and intra-alveolar edema, and hemmorhage. This should be designated respirator-induced lung disease, and such changes might be related to lung surfactant depletion. This study was done to evaluate the relative importance of intrapulmonary positive pressure and oxygen concentrations as causes of respirator-induced lung disease and to determine if there was any relation of this disease to lung surfactant activity.
Twenty-one mongrel dogs were continuously ventilated under approximated clinical conditions for 22 to 70 hr using
Barsch J, Birbara C, Eggers GWN, et al. Positive Pressure as a Cause of Respirator-Induced Lung Disease.. Ann Intern Med. 1970;72:810. doi: https://doi.org/10.7326/0003-4819-72-5-810_1
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Published: Ann Intern Med. 1970;72(5):810.
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