Roger S. Mitchell, M.D., F.A.C.P.; Thomas L. Petty, M.D., (Associate); Giles F. Filley, M.D., F.A.C.P.; Gladys A. Dart, B.A.; G. Wayne Silvers, M.S.; John C. Maisel, M.D.
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Between 1959 and 1968 special studies were made of the lungs from 500 autopsied subjects—mostly men and all over 40 year old—with and without chronic airway obstruction. Attention was focused on  the severity of destructive emphysema and on inflammatory and atrophic changes within the airways and  the speed of airway collapse on the application of 10 cm water positive pressure to lungs inflated in an artificial thorax after the airways had been coated with finely powdered barium and monitored by cinefluoroscopy. The clinical state of chronic airway obstruction correlated well with objective evidence of airway collapse when it
Mitchell RS, Petty TL, Filley GF, et al. The Pathogenesis of Chronic Airway Obstruction.. Ann Intern Med. 1970;72:810. doi: https://doi.org/10.7326/0003-4819-72-5-810_3
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Published: Ann Intern Med. 1970;72(5):810.
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