David A. Mathison, M.D.; John J. Condemi, M.D., F.A.C.P.; Frank W. Lovejoy Jr., M.D.; John H. Vaughan, M.D., F.A.C.P.
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Cromolyn sodium (disodium cromoglycate), an inhibitor of antigen-antibody-induced mediator release, has been shown to prevent acute asthma in allergic subjects when inhaled prior to challenge with inhalant allergens. It has been available for general physician use in Great Britain since 1968 and is undergoing clinical trials in several U. S. centers.
Cromolyn sodium has been administered (20 mg powder inhalation, four or more times daily) in open trial to 29 adults with perennial asthma who had been corticoid-dependent and who completed a 14-week double blind, double crossover trial comparing cromolyn sodium and placebo. Patients kept daily record of symptoms and
Mathison DA, Condemi JJ, Lovejoy FW, Vaughan JH. Cromolyn Sodium Trial in Perennial Asthmatics.. Ann Intern Med. ;72:810–811. doi: 10.7326/0003-4819-72-5-810_4
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Published: Ann Intern Med. 1970;72(5):810-811.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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