EDWARD T. SCHROEDER, M.D.; PATRICIA J. NUMANN, M.D.; BRUCE E. CHAMBERLAIN, M.D.
A 42-year-old woman with alcoholic cirrhosis spontaneously developed severe and prolonged oliguric functional renal failure. After 14 weeks of oliguria, unimproved by plasma expansion, and progressive uremia requiring repeated peritoneal dialysis, a portacaval shunt was constructed to improve renal perfusion. Improvement in renal function began immediately after surgery, and creatinine clearance rose from 8 to 75 ml/min. Presurgical abnormalities of blood pressure, hyperaldosteronism, renal dilution mechanisms, and plasma renin returned to normal or near normal after surgery. Recovery of renal function may have been a result of altered hemodynamics associated with construction of the portacaval shunt.
SCHROEDER ET, NUMANN PJ, CHAMBERLAIN BE. Functional Renal Failure in Cirrhosis: Recovery After Portacaval Shunt. Ann Intern Med. 1970;72:923–928. doi: https://doi.org/10.7326/0003-4819-72-6-923
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Published: Ann Intern Med. 1970;72(6):923-928.
Gastroenterology/Hepatology, Liver Disease, Nephrology.
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