JOSEPH T. DOYLE, M.D., F.A.C.P.
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Uniquely among the primates certain human social groups suffer from widespread atherosclerosis of the aorta and its branches, the ischemic complications of which cause senile decay, strokes, heart attacks, and intermittent claudication. For more than a century it has been known that the composition of the atheroma is identical with that of the fats circulating in the blood plasma. Atheromatosis is the response of the arterial wall to an overload of fat. Under the driving forces of arterial pressure there is a constant outward percolation through the vascular tunics of fat and other plasma constituents that are normally returned to
DOYLE JT. Remediable Precursors of Coronary Artery Disease. Ann Intern Med. 1970;73:131–133. doi: 10.7326/0003-4819-73-1-131
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Published: Ann Intern Med. 1970;73(1):131-133.
Cardiology, Coronary Heart Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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