JOHN J. VOORHEES, M.D.; EMMET HAYES, M.D.; JAMES WILKINS, M.D.; RICHARD E. HARRELL, M.D.
Previous investigators have noted scarring acne in several patients with the XYY chromosomal complement. This prompted our cytogenetic anlysis of an 18-year-old man whose nodulocystic acne apparently began at age 3. Morphologic studies and tritiated thymidine labeling of chromosomes prepared from his peripheral blood and skin cells showed an XYY sex-chromosome constitution. The unusually early onset of cystic lesions suggests that acne and the XYY genotype in this patient might be more than coincidental. Further study of the possible value of nodulocystic acne as a clinical marker of persons with an increased XYY risk is warranted. A comparison of XX, XY, and XYY subjects with and without cystic acne might show variations in Y-regulated gene products important to the pathobiology of acne.
VOORHEES JJ, HAYES E, WILKINS J, et al. The XYY Chromosomal Complement and Nodulocystic Acne. Ann Intern Med. 1970;73:271–276. doi: https://doi.org/10.7326/0003-4819-73-2-271
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Published: Ann Intern Med. 1970;73(2):271-276.
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