WILLIAM M. BIRTWELL, M.D.; JOHN H. MARTIN, M.D.
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To the editor: We read with interest the recent report by Ackerman (Ann Intern Med 72:511-519, 1970) and feel the following should be reemphasized. We, and others, have noted a relatively weak effect of intermittent corticoid and corticotrophin administration on basic phenomena, such as homograft rejection, skin hypersensitivity, reticuloendothelial phagocytic function, and lymphocyte transformation (1-5). These processes are profoundly affected by sustained corticoid administration. Consequently, we have been disappointed rather than encouraged.
This concern has led us to follow very closely the clinical response of patients receiving alternate-day corticoid therapy. We follow the practice of considering sustained administration whenever there
BIRTWELL WM, MARTIN JH. Intermittent vs Sustained Steroid Therapy. Ann Intern Med. 1970;73:494. doi: https://doi.org/10.7326/0003-4819-73-3-494
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Published: Ann Intern Med. 1970;73(3):494.
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