STANLEY J. BODNER, M.D.; M. GLENN KOENIG, M.D., F.A.C.P.; JAY S. GOODMAN, M.D., F.A.C.P.
Thirty-nine patients with bacteremia due to anaerobic Gram-negative bacilli of the genus Bacteroides were seen in a general hospital during a 6-year period. Many of these infections occurred in patients postoperatively, particularly after trauma to the bowel or female pelvic organs. There was an impressive prevalence of malignant neoplasms, diabetes mellitus, and prior therapy with corticoids or multiple antimicrobials. The Bacteroides strains isolated tended to be resistant to the bacteriocidal antibiotics used for treating Gram-negative bacillary sepsis (penicillin, cephalothin, kanamycin, and Colistin). Ten strains were resistant to tetracycline, a drug widely recommended for bacteroides infections. Of 38 isolates tested all were susceptible to chloramphenicol. Diagnosis of bacteroides sepsis demands a high index of suspicion and routine use of anaerobic cultures. Successful therapy depends on early surgical debridement and institution of appropriate antibiotics. In the absence of sensitivity data bacteroides sepsis appears to represent another of the few indications for therapy with chloramphenicol.
BODNER SJ, KOENIG MG, GOODMAN JS. Bacteremic Bacteroides Infections. Ann Intern Med. 1970;73:537–544. doi: 10.7326/0003-4819-73-4-537
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Published: Ann Intern Med. 1970;73(4):537-544.
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