GEORGE A. BRAY, M.D., F.A.C.P.
The size of subcutaneous fat cells was measured with a microscope after separating the cells by digestion in collagenase. Obese patients had large cells averaging 0.78 nl in volume, whereas the average volume of fat cells from the control subjects was only 0.26 nl. In this latter group fat cell volume was positively correlated with body weight. Many obese subjects had an increased number of fat cells. With weight loss the size of individual fat cells decreased, but the total number of fat cells did not.
BRAY GA. Measurement of Subcutaneous Fat Cells from Obese Patients. Ann Intern Med. ;73:565–569. doi: 10.7326/0003-4819-73-4-565
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Published: Ann Intern Med. 1970;73(4):565-569.
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