KARL A. WESTERN, M.D.; DAVID R. PERERA, M.D.; MYRON G. SCHULTZ, D.V.M., M. D.
In an 18-month period 164 patients with suspected or proved interstitial pneumonia due to Pneumocystis carinii were treated with pentamidine isethionate. Side effects were noted in 69 patients. Local pain, abscess formation, and ulceration were clearly attributable to pentamidine administration. Azotemia, hypoglycemia, and changes in liver function occurred frequently during therapy. Pentamidine may have been responsible for two deaths. Seventy-five of the patients who received pentamidine had documented P. carinii pneumonia; 36 of the 75 patients recovered. All 75 had a serious underlying disease, and 60 were on immunosuppressive therapy.
WESTERN KA, PERERA DR, SCHULTZ MG. Pentamidine Isethionate in the Treatment of Pneumocystis carinii Pneumonia. Ann Intern Med. 1970;73:695–702. doi: https://doi.org/10.7326/0003-4819-73-5-695
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Published: Ann Intern Med. 1970;73(5):695-702.
Infectious Disease, Pneumonia, Pulmonary/Critical Care.
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