MARTIN C. MCHENRY, M.D.; THOMAS L. GAVAN, M.D.; RAY W. GIFFORD JR., M.D.; NATHAN A. GEURKINK, M.D.; RAY A. VAN OMMEN, M.D.; MARY ANN TOWN, M.T.; JOHN G. WAGNER, Ph.D.
The percent hourly loss and serum half-life (T½) of gentamicin were determined after an intramuscular dose of from 0.8 to 1.5 mg/kg body weight in each of 18 patients with various degrees of impaired renal function and in 6 patients with normal renal function. There was a linear relationship between the loss of gentamicin and the endogenous creatinine clearance (CCr). The percent hourly loss could be estimated by dividing the value of the CCr (ml/min/1.73 m2 body surface area) by four. There was a curvilinear relationship between the serum creatinine concentration and the T½ of gentamicin. The nature of the curve was such that for clinical purposes the T½ of gentamicin could be estimated by multiplying the value of the serum creatinine (mg/100 ml) by four. These data provide a possible basis for individualized adjustment of dosage of gentamicin for patients with impaired renal function.
MCHENRY MC, GAVAN TL, GIFFORD RW, GEURKINK NA, VAN OMMEN RA, TOWN MA, et al. Gentamicin Dosages for Renal Insufficiency: Adjustments Based on Endogenous Creatinine Clearance and Serum Creatinine Concentration. Ann Intern Med. ;74:192–197. doi: 10.7326/0003-4819-74-2-192
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Published: Ann Intern Med. 1971;74(2):192-197.
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