MARC VERSTRAETE, M.D., F.A.C.P.; JOSEPH VERMYLEN, M.D.; MARIA BENEDETTA DONATI, M.D.
In 23 men with atherosclerosis of the distal abdominal aorta or more peripheral arteries, 35 arterial occlusions and 26 major arterial stenoses were visualized at angiography; these patients were treated with streptokinase using a standard dosage scheme. Twenty-eight of the 35 arterial occlusions were not modified by the thrombolytic therapy, 3 were totally and 4 partially lysed. In one patient complete removal of the obstruction was followed by reocclusion within 48 hr. The outcome appeared to be influenced by the duration, the length, and the location of the occlusion. Of the 26 major arterial stenoses, only 1 was definitely removed; another was transformed into a complete occlusion during streptokinase administration. Side effects of the therapy included 1 death, 7 instances of bleeding, 1 instance of thrombophlebitis, 1 case of bronchospasm, and 14 febrile reactions. Streptokinase therapy of chronic arterial occlusions and stenoses appears to be of limited value.
VERSTRAETE M, VERMYLEN J, DONATI MB. The Effect of Streptokinase Infusion on Chronic Arterial Occlusions and Stenoses. Ann Intern Med. ;74:377–382. doi: 10.7326/0003-4819-74-3-377
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Published: Ann Intern Med. 1971;74(3):377-382.
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