RICHARD SELDEN, M.D.; SHARON LEE, B.A.; WEN LAN LOU WANG, PH.D.; JOHN V. BENNETT, M.D.; THEODORE C. EICKHOFF, M.D.
A prospective study of patients admitted to a hospital where there was endemic nosocomial infection with multidrug-resistant klebsiella was undertaken to evaluate the role of intestinal colonization of patients. Among 31 patients who became intestinal carriers of klebsiella during hospitalization, 14 subsequently became infected by the same serotype. Of 101 patients who did not become intestinal carriers of klebsiella, only 11 were infected by that organism. Antibiotic therapy was shown to be predisposing to intestinal colonization with klebsiella and to exert a selective pressure in favor of multidrug-resistant klebsiella. Gastrointestinal acquisition and carriage of klebsiella by patients may be an
SELDEN R, LEE S, WANG WLL, et al. Nosocomial Klebsiella Infections: Intestinal Colonization as a Reservoir. Ann Intern Med. 1971;74:657–664. doi: 10.7326/0003-4819-74-5-657
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Published: Ann Intern Med. 1971;74(5):657-664.
Gastroenterology/Hepatology, Infectious Disease.
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