DAVID GREEN, M.D.; HECTOR A. BATTIFORA, M.D.; ROY T. SMITH, M.D.; ENNIO C. ROSSI, M.D.
A 63-year-old man with Gaucher's disease presented with bleeding secondary to thrombocytopenia. Bone marrow examination showed many typical Gaucher cells and adequate numbers of megakaryocytes. A 51Cr platelet survival study indicated a markedly shortened half-disappearance time of 0.8 days and a major uptake of the 51Cr label by the spleen. After splenectomy the platelet count rose to normal levels, and a repeat survival study showed a normal half-disappearance time of 5.1 days. Electron-microscopic analysis of the spleen disclosed intact platelets within the Gaucher cells. These studies indicate that the spleen plays an important role in the pathogenesis of the thrombocytopenia by virtue of its large content of Gaucher cells.
GREEN D, BATTIFORA HA, SMITH RT, ROSSI EC. Thrombocytopenia in Gaucher's Disease. Ann Intern Med. 1971;74:727–731. doi: 10.7326/0003-4819-74-5-727
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Published: Ann Intern Med. 1971;74(5):727-731.
Encephalopathy, Hematology/Oncology, Neurology, Platelet Disorders.
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