NORTON J. GREENBERGER, M.D.
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Neuvonen and his associates (1) have recently reported that ferrous sulfate taken by mouth with tetracycline or a tetracycline-derivative can impair the absorption of these antibiotics. These investigators demonstrated in human volunteers that after a single 500-mg dose of tetracycline a maximal serum concentration of 2.9 µg/ml was attained in a 6-hr period, but, when tetracycline was taken with 200 mg of FeSO4, the maximal serum levels were only 40% to 50% of levels after tetracycline alone. Similarly, ingestion of 500 mg of Oxytetracycline and 200 mg of FeSO4 resulted in serum levels 50% to 60% lower than the value
GREENBERGER NJ. Absorption of Tetracyclines: Interference by Iron. Ann Intern Med. ;74:792–793. doi: 10.7326/0003-4819-74-5-792
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Published: Ann Intern Med. 1971;74(5):792-793.
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