HOWARD V. DUBIN, M.D.; E. RICHARD HARRELL, M.D.
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To the editor: In the December 1970 issue of the ANNALS Vogler and Olansky (1) presented a double-blind study of azaribine (6-azauridine triacetate) in the treatment of psoriasis. They showed, as did Turner and Calabresi (2) in 1964, that this drug was effective in the treatment of psoriasis. They stated that "toxicity was mainly hemopoietic but was not severe and was usually reversed with dose reduction." They went on to say that "except for the hematologic effects, azaribine appeared to be nontoxic." In light of the recent multiple studies (3-6) showing severe liver disease associated with long-term use of methotrexate,
DUBIN HV, HARRELL ER. Azaribine in the Treatment of Psoriasis. Ann Intern Med. 1971;74:797–798. doi: 10.7326/0003-4819-74-5-797
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Published: Ann Intern Med. 1971;74(5):797-798.
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