I. Barr, M.D.; M. D. Klein, M.D.; B. Lown, M.D.; T. Smith, M.D.; F. Hagemeijer, M.D.
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With the advent of a reliable radioimmunoassay it has become possible to quantify serum digoxin levels. Whereas a high serum digoxin level helps confirm toxicity, some overlap with therapeutic glycoside levels exists. In the presence of a normal digoxin level proximity to a toxic state cannot be defined with precision. Degree of digitalization was therefore assessed by both serum digoxin levels and an independent pharmacoassay using acetylstrophanthidin. In 10 anesthetized dogs given 0.04 to 0.08 mg/kg body weight digoxin intravenously 6 hr earlier, the serum digoxin level inversely correlated with the amount of acetylstrophanthidin required to produce ventricular tachycardia (r
Barr I, Klein MD, Lown B, et al. Correlation of Serum Digoxin Level with Acetylstrophanthidin Tolerance.. Ann Intern Med. 1971;74:817. doi: https://doi.org/10.7326/0003-4819-74-5-817_1
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Published: Ann Intern Med. 1971;74(5):817.
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