Richard A. DeWall, M.D.; Kent A. Vasko, D.V.M.
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Allopurinol is a xanthine oxidase inhibitor that has the potential of preserving nucleotide base and, therefore, both energy and electrolytic activity in cells. Digitalis toxicity was produced in experimental animals, using oubain and lanatoside C (Cedilanid®). These agents were infused until dysrhythmia developed. Sodium allopurinol was then administered by intravenous infusion until a level of 100 mg/kg body weight was reached. Measurements of the ECG and arterial and central venous pressures were obtained. Blood samples were collected from a systemic artery and vein and coronary sinus for measurement of pH, PO2, PCO2, K+, inorganic phosphorous, and glucose. The measurements were
DeWall RA, Vasko KA. The Effects of Sodium Allopurinol in Digitalis Toxicity.. Ann Intern Med. ;74:819. doi: 10.7326/0003-4819-74-5-819_3
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Published: Ann Intern Med. 1971;74(5):819.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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