J. Gerard Mudd, M.D.; Vallee L. Willman, M.D.; Leonard Fagan, M.D.; Yavuz Aykent, M.D.
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Of the 475 patients with isolated ventricular septal defect diagnosed over the past 18 years by catheterization and cineangiography, 285 were observed for their natural history, and 190 had surgery. The unoperated patients were divided into two groups: those with pulmonary artery systolic pressure less than 50 mm Hg and those with pulmonary artery systolic pressure greater than 50. In the first group 238 patients have been observed 1 to 17 years and have shown no evidence of deterioration. Serial catheterization in 59 patients showed no progression of hypertension or shunt. Nine patients had spontaneous closure. Of 47 patients with
Mudd JG, Willman VL, Fagan L, et al. Natural and Postoperative History of 475 Patients with Proved Isolated Ventricular Septal Defects.. Ann Intern Med. 1971;74:820. doi: https://doi.org/10.7326/0003-4819-74-5-820_5
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Published: Ann Intern Med. 1971;74(5):820.
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