Allan B. Schwartz, M.D.; Virgilio Paz-Martinez, M.D.; Kwan Eun Kim, M.D. (Member); Gaddo Onesti, M.D.; Joel L. Chinitz, M.D.; Charles Swartz, M.D., F.A.C.P.
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Clonidine (Catapres⌖) is a new imidazoline derivative with potent antihypertensive effect. The acute hemodynamic effects of Clonidine were evaluated in seven hypertensive patients. Two distinct hemodynamic patterns are seen, depending on the position of the patient. In the supine posture cardiac output is reduced 21%, and no change occurs in peripheral vascular resistance. On tilting upright 45 deg, blood pressure is further reduced, with only minimal reduction of cardiac output; however, a 20% reduction of peripheral vascular resistance is the rule in the upright posture. The decrease in arterial blood pressure is associated with a decrease in renal vascular resistance
Schwartz AB, Paz-Martinez V, Kim KE, et al. Clonidine, a New Potent Antihypertensive Agent.. Ann Intern Med. 1971;74:821. doi: https://doi.org/10.7326/0003-4819-74-5-821_3
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Published: Ann Intern Med. 1971;74(5):821.
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