Robert H. Seller, M.D., F.A.C.P.; Stanley Banach, M.D.; Martin Neff, M.D.; Thomas Namey, M.S.; Charles Swartz, M.D., F.A.C.P.
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Diuretic drugs affect the renal tubular secretion of potassium. Triamterene, ethacrynic acid, and furosemide were studied to determine whether they modified the digitalis-induced myocardial egress of potassium, which is thought to facilitate the development of digitalis arrhythmias. In a control group of 16 dogs potassium was measured in samples obtained simultaneously from the femoral artery and coronary sinus, twice in a control period and at 2-min intervals after the administration of 1 mg of acetylstrophanthidin into the right atrium. Coronary blood flow, blood pressure, and ECG were monitored. Acetylstrophanthidin caused a significant egress of myocardial potassium (coronary sinus to femoral
Seller RH, Banach S, Neff M, et al. The Myocardial Effect of Diuretic Drugs.. Ann Intern Med. 1971;74:821. doi: 10.7326/0003-4819-74-5-821_4
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Published: Ann Intern Med. 1971;74(5):821.
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