Katsutaro Shimaoka, M.D.; J. E. Sokal, M.D., F.A.C.P.
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Patients with nontoxic nodular goiter were treated with T8, 50 µg/day, or T4, 200 µg/day, in a double-blind study. Their nodules were measured independently by two examiners at 4-week intervals, without access to previous measurements or to the results of thyroid function studies. The study lasted for 28 weeks; phase 1 for 12 weeks and phase 2 for 16 weeks. At the end of phase 1, decrease in goiter size was evident in 47% of the patients, who were carried on to phase 2 without dosage modification. The others were then randomized to continue the same medication at the same
Shimaoka K, Sokal JE. Comparison of L-Thyroxine (T4) and L-Triiodothyrone (T8) in Suppressive Therapy of Nontoxic Nodular Goiter.. Ann Intern Med. ;74:825. doi: 10.7326/0003-4819-74-5-825_1
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Published: Ann Intern Med. 1971;74(5):825.
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