Joseph M. Cardamone, M.D.; J. Roger Edson, M.D.; James R. McArthur, M.D.; Harry S. Jacob, M.D.
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A hemorrhagic diathesis frequently complicates myeloproliferative disorders, yet its pathogenesis remains enigmatic. The frequency of abnormalities in platelet morphology in these disorders suggests platelet malfunction might underlie this defective hemostasis. Platelet function tests were performed on 21 consecutive patients with various myeloproliferative disorders (polycythemia vera, myelogenous leukemia, myelofibrosis, and erythroleukemia). Tests included platelet adhesiveness (Salzmann), factor 3 release (Russel's viper venom method), agregation induced by adenosine diphosphate, collagen and catechols, and Ivy bleeding time. All 21 patients demonstrated at least one platelet dysfunction. Multiple abnormalities correlated with increasing clinical severity of the hemorrhagic diathesis. Platelet aggregation was most often abnormal:
Cardamone JM, Edson JR, McArthur JR, Jacob HS. Abnormal Platelet Function in the Myeloproliferative Disorders.. Ann Intern Med. 1971;74:826. doi: 10.7326/0003-4819-74-5-826_3
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Published: Ann Intern Med. 1971;74(5):826.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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