R. D. Lange, M.D., F.A.C.P.; Tommye Jordon, M.T.; L. C. McKee, M.D.
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Although erythropoietin (erythropoiesis-stimulating factor (ESF)) is thought to be the physiological regulator of erythropoiesis, the proof is indirect since it is impossible by bioassay techniques to measure ESF levels in normal serum. With the development of an immunoassay such measurements became possible. The occurrence of ESF in serum of normal blood donors and the results of measurements of ESF serum levels at different times of the day are reported. The results of a correlation study of hematocrit levels with ESF levels will also be presented. The ESF in serum was measured by the hemagglutination-inhibition assay method, and, where feasible, sera
Lange RD, Jordon T, McKee LC. Erythropoietin in the Control of Normal Erythropoiesis.. Ann Intern Med. 1971;74:827. doi: 10.7326/0003-4819-74-5-827_2
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Published: Ann Intern Med. 1971;74(5):827.
DOI: 10.7326/0003-4819-74-5-827_2