J. M. Martinez, M.D.; S. S. Shapiro, M.D.
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Simultaneous studies of the metabolism of 125I-prothrombin and 131I-fibrinogen were performed in seven patients with thrombocytosis associated with myeloproliferative states. Platelet counts ranged from 600,000 to 3,000,000/mm3. The mean fractional catabolic rate of prothrombin was 60% of the plasma pool per day, a significant increase over the normal mean rate of 42.5% (P < 0.01) The mean fractional catabolic rate of fibrinogen was 34%, significantly increased over the normal mean of 24% (P < 0.01). Correlation between the increased rates of fibrinogen and prothrombin was excellent. Fractional catabolic rates returned to normal in two patients restudied after busulfan treatment restored
Martinez JM, Shapiro SS. Coagulation Protein Turnover in Patients with Thrombocytosis.. Ann Intern Med. 1971;74:827. doi: https://doi.org/10.7326/0003-4819-74-5-827_3
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Published: Ann Intern Med. 1971;74(5):827.
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