John R. Burton, M.D.; S. Sterioff, M.D.; J. B. Zachary, M.D.; G. M. Williams, M.D.; J. R. Wright, M.D.; R. E. Slavin, M.D.; W. B. Greenough III, M.D.; Howard K. Rathbun, M.D.
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Disseminated aspergillosis has killed many patients who were being treated with immunosuppressive agents after organ transplantation. Few cases were recognized in patients before death, and those that were discovered were in terminally ill patients, and therapy was ineffective.
Four patients infected with Aspergillus fumigatus after renal homotransplantation are described. All infections were controlled successfully with amphotericin B. Immune suppression was continued and rejection crises treated with high doses of corticoids without extension of the fungal disease. Three of the patients required open lung biopsy to establish the diagnosis and stimulate accurate and prompt therapy. One patient was treated without biopsy
Burton JR, Sterioff S, Zachary JB, et al. Early Diagnosis, Key to Control of Aspergillosis After Kidney Transplantation.. Ann Intern Med. 1971;74:828. doi: 10.7326/0003-4819-74-5-828_2
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Published: Ann Intern Med. 1971;74(5):828.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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