Daniel E. Lehane, M.D.; Neil R. Newberg, M.D.; Walter E. Beam
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Several investigators have demonstrated rising Epstein Barr (EB) virus antibody titers in infectious mononucleosis. Since most EB virus infections go unrecognized and EB virus has been associated with several other conditions, the causal relationship of EB virus to infectious mononucleosis remains uncertain. We have attempted to clarify this relationship by describing primary EB virus infections in terms of serum and nasal secretory immunoglobin responses. The clinical manifestations of infectious mononucleosis have been determined by reviewing 66 documented cases, and a mild illness similar to mononucleosis has been demonstrated during typical EB virus infections.
Serum and nasal secretion specimens collected biweekly
Lehane DE, Newberg NR, Beam WE. Clinical and Immunologic Features of Primary EpsteinBarr Virus Infection and Infectious Mononucleosis.. Ann Intern Med. 1971;74:828. doi: 10.7326/0003-4819-74-5-828_3
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Published: Ann Intern Med. 1971;74(5):828.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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