Nathaniel F. Pierce, M.D., F.A.C.P.
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The present whole-cell cholera vaccine stimulates only antibacterial antibodies and provides limited protection of brief duration. Since the effects of cholera are produced by a protein enterotoxin, it is possible that antitoxic immunity might provide an additional and perhaps more effective means of protection. The protective value of antitoxic immunity was evaluated in a canine model of the disease. Dogs were immunized parenterally with highly purified cholera entertoxin plus adjuvant and given a booster after 28 days. High serum antitoxin titers developed and persisted at 10 times preimmunization values for more than 300 days. Serum vibriocidal antibody titers did not
Pierce NF. Antitoxic Immunity to Cholera.. Ann Intern Med. 1971;74:828. doi: https://doi.org/10.7326/0003-4819-74-5-828_5
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Published: Ann Intern Med. 1971;74(5):828.
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