Barry D. Wenglin, M.D.; Douglas W. Voth, M.D.; Murli Manohar, Ph.D.; Chien Liu, M.D.
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Encephalitis caused by herpes virus hominis is generally a serious disease. Although most patients may present with a short course of fever, headache, convulsions and obtundness, there are no pathognomonic signs and symptoms to permit definitive diagnosis. Routine laboratory studies including cerebrospinal fluid (CSF) examinations are usually not helpful. Herpes virus, as a rule, cannot be isolated from CSF specimens.
Within 5 years, 10 patients had encephalitis caused by herpes virus as confirmed by positive immunofluorescent staining of viral antigen and virus isolation in the brain, and high serum antibody titers against herpes virus hominis. The etiologic diagnosis for the
Wenglin BD, Voth DW, Manohar M, et al. Clinical and Laboratory Experiences with Encephalitis due to Herpes Virus Hominis.. Ann Intern Med. 1971;74:829. doi: 10.7326/0003-4819-74-5-829_3
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Published: Ann Intern Med. 1971;74(5):829.
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