Albert A. Carr, M.D.
This content is PDF only. Please click on the PDF icon to access.
Many of the prostaglandins have vasoactive and metabolic properties. One of these cyclic fatty acids, PGA1, may be an ideal antihypertensive agent because it has predominately vasodepressor activity. A drop in arterial blood pressure is one of the main stimuli of renin release. Since prostaglandins and renin are found in the kidney and both are possibly involved in blood pressure control, it is important to determine a possible reciprocal relationship. PGA1 was given by peripheral-vein infusion to patients with essential hypertension. Unlike other vasodepressors, such as sodium nitroprusside, hydralazine, and diazoxide, which cause renin release, PGA1 given in amounts that
Carr AA. Prostaglandin (PGA1), Blood Pressure, Plasma Renin Activity.. Ann Intern Med. 1971;74:830. doi: 10.7326/0003-4819-74-5-830_4
Download citation file:
Published: Ann Intern Med. 1971;74(5):830.
Copyright © 2019 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use