H. B. Kelso, M.D.; C.C. Tisher, M.D.; J. C. Gunnells, M.D., F.A.C.P.; R. R. Robinson, M.D., F.A.C.P.; P. M. Burkholder, M.D.
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Intraendothelial paramyxovirus-like structures have been reported in renal glomeruli of patients with systemic lupus erythematosus (SLE). Their specificity, etiologic significance, and possible contribution to the pathogenesis of lupus nephritis and SLE remain unclear. The renal biopsy experience at Duke University was reviewed to determine the clinicopathologic correlates and incidence of these structures in proved SLE. Renal biopsies of 26 patients with proved SLE (group I) were studied by light, immunofluorescent, and electron microscopy and compared with 211 biopsies from patients with a variety of primary and secondary diseases (group II). In Group I 23 out of 26 biopsies exhibited intraendothelial
Kelso HB, Tisher C, Gunnells JC, et al. Paramyxovirus-Like Structures in Kidneys of Patients with Systemic Lupus Erythematosus.. Ann Intern Med. 1971;74:831. doi: 10.7326/0003-4819-74-5-831_3
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Published: Ann Intern Med. 1971;74(5):831.
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