William J. Mroczek, M.D.; Michael Davidov, M.D.; Frank A. Finnerty Jr., M.D.
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The exaggerated natriuresis and diuresis of hypertensive patients to a hypertonic saline infusion was investigated to determine the importance of the beta adrenergic nervous system and cardiac hemodynamics. Six hypertensive and four normotensive patients received a hypertonic saline load (100 ml of 5% saline/m2 body surface area) before and after beta adrenergic blockade. During the 3 hr after the hypertonic saline loading the hypertensive patients excreted 79% (129 of 158 mEq Na), and the normotensive patients excreted 37% (60 of 162 mEq Na) of the load; whereas after 2 weeks of oral propranolol (120 to 340 mg daily), the hypertensive
Mroczek WJ, Davidov M, Finnerty FA. The Effect of Beta Adrenergic Blockade on the Exaggerated Natriuresis and Diuresis of Hypertensive Patients.. Ann Intern Med. 1971;74:832. doi: 10.7326/0003-4819-74-5-832_1
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Published: Ann Intern Med. 1971;74(5):832.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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