D. A. Ogden, M.D., F.A.C.P.; B. Hulme, M.D.; K. A. Porter, M.D.
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The ultrastructure and function of the glomerular basement membrane was studied in 44 patients, 4 to 35 months after transplantation. Tissue from 47 biopsies was examined by light, immunofluorescence, and electron microscopy. Glomerular function was evaluated by creatinine clearance, 24-hr protein excretion, and measurement of graded macromolecular permeability with polydispersed 125I polyvinylpyrrolidone (PVP). The patients were grouped according to observed glomerular ultrastructure. Group A was normal; group B showed slight focal subendothelial deposits; in group C there were moderate to marked subendothelial deposits; in group D there were mesangial proliferation, subendothelial deposits, and infiltration of the lamina densa; in group
Ogden DA, Hulme B, Porter KA. Glomerular Ultrastructure and Functional Integrity in the Human Renal Transplant.. Ann Intern Med. ;74:832. doi: 10.7326/0003-4819-74-5-832_3
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Published: Ann Intern Med. 1971;74(5):832.
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