Richard F. Spark, M.D.; James C. Melby, F.A.C.P.
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Persistently hyporesponsive plasma renin activity is characteristic of primary aldosteronism and other forms of primary mineralocorticoid excess. Twenty percent of patients with essential hypertension have low renin responsiveness, yet secretion of known mineralocorticoids is normal or low in these patients. If mineralocorticoid excess is the cause of the hyporesponsive renin activity and is contributing to the hypertension in these patients, then spironolactone, a mineralocorticoid antagonist, should reverse the hypertension in these selected cases. Eight hypertensive study patients (blood pressure, 178/116 mm Hg) with low plasma renin activity and low aldosterone secretory rate were studied with a comparison group of 15
Spark RF, Melby JC. Hypertension and Low Plasma Renin Activity: Presumptive Evidence for Mineralocorticoid Excess.. Ann Intern Med. 1971;74:833. doi: https://doi.org/10.7326/0003-4819-74-5-833_3
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Published: Ann Intern Med. 1971;74(5):833.
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