Donald J. Glotzer, M.D.; Louis Zetzel, M.D.; Richard C. Gardner, M.D.; H. Richard Hinrichs, M.D.; Harvey Goldman, M.D.
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In 95 patients with resections for colonic inflammation the histologic features were assessed blindly to determine whether these were distinctive for ulcerative or granulomatous colitis and whether they predicted the clinical behavior. There were statistically highly significant relationships between the following: sinus tracts (fissures) with noncaseating granulomas; segmental disease with sinus tracts and granulomas; clinical criteria of granulomatous colitis with sinus tracts and granulomas; and clinical criteria of ulcerative colitis with absence of sinus tracts and granulomas. Granulomatous colitis could be best diagnosed on the basis of combined criteria rather than by purely clinical or microscopic criteria. Considering other features
Glotzer DJ, Zetzel L, Gardner RC, et al. The Histopathologic and Clinical Spectrum of Granulomatous and Ulcerative Colitis.. Ann Intern Med. 1971;74:834. doi: https://doi.org/10.7326/0003-4819-74-5-834_3
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Published: Ann Intern Med. 1971;74(5):834.
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