F. Marc LaForce, M.D.; Richard F. Boehme, M.D.; Gary L. Huber, M.D.
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Despite the well-known relationship between pulmonary edema and bacterial pneumonia, the behavior of host defense mechanisms against inhaled bacteria in the edematous lung remains unclear. To evaluate this problem pulmonary edema was pharmacologically induced in laboratory mice with alpha naphthyl thiourea (ANTU: 0.08 mg/g) administered intraperitoneally. Control animals and mice given ANTU were challenged with an aerosol of radiolabeled 32P Staphylococcus aureus. Animals were then sacrificed at zero, 2, 4, and 6 hr after bacterial challenge and intrapulmonary bacterial inactivation determined by quantitating the change in bacterial viability (colony counts of pour-plate dilutions) and bacterial clearance (radioisotopic activity) in homogenized
LaForce FM, Boehme RF, Huber GL. The Effect of Pulmonary Edema on Antibacterial Defense Mechanisms of the Lung.. Ann Intern Med. ;74:840. doi: 10.7326/0003-4819-74-5-840_3
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Published: Ann Intern Med. 1971;74(5):840.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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