Solomon A. Berson, M.D.
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Within the past decade radioimmunoassays have been developed for most of the peptide hormones. Recent studies have explored the state of these hormones in plasma and endocrine glands. Unlike the thyroidal and steroidal hormones that circulate largely or partly as protein-bound complexes, the peptide hormones appear to be free in the plasma, notwithstanding earlier suggestions that they too may be bound to plasma proteins. Evidence has accumulated, however, that peptide hormones may be present in at least two forms in plasma. Heterogenicity of plasma parathyroid hormone was detected by differences in reaction with different antisera. Proinsulin in plasma was shown
Berson SA. The American College of Physicians Award Lecture: Heterogenicity of Peptide Hormones Revealed by Radioimmunoassays.. Ann Intern Med. 1971;74:843. doi: https://doi.org/10.7326/0003-4819-74-5-843_2
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Published: Ann Intern Med. 1971;74(5):843.
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