E. De Robertis, F.A.C.P., (Hon.)
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Electron microscopy, in conjunction with cell fractionation and neurochemical studies, has greatly advanced our knowledge of chemical synapses in the central nervous system.
The isolation of nerve endings and the recognition that synaptic vesicles are the sites of storage of the transmitters in quantal units have led to a better understanding of the mechanisms by which these active substances are synthesized, stored, released, reuptaken, or degraded, opening the possibility of a direct investigation of the action of neuro- and psycho-active drugs.
Special emphasis will be placed on the separation of the nerve-ending membranes and junctional complexes with their important membrane-bound
De Robertis E. The Lilly Lecture: Macromolecular Organization of Chemical Synapses in the Central Nervous System.. Ann Intern Med. 1971;74:843. doi: 10.7326/0003-4819-74-5-843_4
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Published: Ann Intern Med. 1971;74(5):843.
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