J. Edwin Seegmiller, M.D.
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Most of the clinical manifestations of gouty arthritis can be directly related to the limited solubility of uric acid and its salts in biological fluids. Deposition of crystals of monosodium urate in and about the joints, tendons, and renal parenchyma gives rise to the acute attacks of gout and joint destruction and contributes to the renal damage of this disease. Deposits of free uric acid at the lower pH encountered in the urinary tract also contribute to renal damage and a rate of renal calculus formation around a thousand times that of the general population. The underlying hyperuricemia results from
Seegmiller JE. Diseases of Uric Acid Metabolism.. Ann Intern Med. 1971;74:844. doi: https://doi.org/10.7326/0003-4819-74-5-844_3
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Published: Ann Intern Med. 1971;74(5):844.
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