DAVID F. PAWLIGER, M.D.; FREDERICK W. MCLEAN, M.D.; WARD D. NOYES, M.D.
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To the editor: Cytosine arabinoside (ARA-C) induces remissions in a significant number of patients with acute granulocytic leukemia (1-3). Although there are observations on the effects of ARA-C in pregnant laboratory animals and their fetuses (4), there are no reports of its use in human pregnancy.
A 23-year-old white woman was hospitalized in October 1969 with high WBC count, anemia, fever, splenomegaly, and cutaneous infections. Her last menstrual period began 29 April 1969, and she had a positive pregnancy test in June. The uterus was enlarged to the umbilicus, and fetal heart sounds were present. Laboratory results included hematocrit 28;
PAWLIGER DF, MCLEAN FW, NOYES WD. Normal Fetus After Cytosine Arabinoside Therapy. Ann Intern Med. ;74:1012. doi: 10.7326/0003-4819-74-6-1012_1
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Published: Ann Intern Med. 1971;74(6):1012.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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