DANIEL K. ONION, M.D.; CLYDE S. CRUMPACKER, M.D.; BRUCE C. GILLILAND, M.D.
Three patients presented with rash and polyarthritis as a prodrome of hepatitis. They initially had Australia antigen and depressed complement levels in both synovial fluid and serum. With the onset of clinically apparent jaundice, the arthritis resolved, serum complement returned to normal, and Australia antigen was no longer detectable in the serum. Subsequently, antibody to Australia antigen appeared. These observations are similar to the events in experimental serum sickness and strongly suggest that circulating immune complexes may be responsible for at least the arthritic manifestations of hepatitis associated with Australia antigen.
ONION DK, CRUMPACKER CS, GILLILAND BC. Arthritis of Hepatitis Associated with Australia Antigen. Ann Intern Med. 1971;75:29–33. doi: https://doi.org/10.7326/0003-4819-75-1-29
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Published: Ann Intern Med. 1971;75(1):29-33.
Gastroenterology/Hepatology, Liver Disease, Rheumatology.
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