J. STAUFFER LEHMAN JR., M.D.; ZOHEIR FARID, M.D.; SAMIR BASSILY, M.D.; DONALD C. KENT, M.D., F.A.C.P.
Renal function was studied in 84 male patients with Schistosoma haematobium infection. Maximal urine concentration, creatinine clearance, and intravenous urography were obtained. Patients were placed in four groups: A, 32 patients with nonobstructive urographic abnormalities and negative urine cultures; B, 24 patients with bilateral hydronephrosis and negative urine cultures; C, 13 patients with nonobstructive urographic abnormalities and bacteriuria; and, D, 15 patients with bilateral hydronephrosis and bacteriuria. Maximal urine concentration in groups B, C, and D was significantly lower than in group A. After antischistosomal and antimicrobial therapy, reduction of hydronephrosis and bacteriuria was associated with significantly increased maximal urine concentration. Creatinine clearance did not change after treatment. The results of this study suggest that hydronephrosis or bacteriuria alone impairs urine concentration, that the effects of both abnormalities on renal concentrating mechanisms may be additive, and that impaired urine concentration owing to either or both is reversible.
LEHMAN JS, FARID Z, BASSILY S, et al. Hydronephrosis, Bacteriuria, and Maximal Urine Concentration in Urinary Schistosomiasis. Ann Intern Med. 1971;75:49–55. doi: 10.7326/0003-4819-75-1-49
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Published: Ann Intern Med. 1971;75(1):49-55.
DOI: 10.7326/0003-4819-75-1-49
Infectious Disease, Nephrology, Urinary Tract Infection, Urological Disorders.
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