J. HIRSH, M.D., F.R.A.C.P.
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To the editor: May I comment on the letter to the Editor by Dr. Jerzy Gajewski, in the March issue of the ANNALS, on "Thrombolytic Therapy and Fatal Massive Pulmonary Emboli." The possibility that treatment of venous thrombosis with thrombolytic agents may induce pulmonary embolism is often raised, but, as Dr. Gajewski points out, the reported incidence of this association is low (1). We have previously noted evidence of rethrombosis in patients with deep-vein thrombosis treated with streptokinase. This tends to occur when the plasminogen falls to low levels, at which time the thrombin time begins to return to normal
HIRSH J. Thrombolytic Therapy and Fatal Pulmonary Emboli. Ann Intern Med. ;75:140–141. doi: 10.7326/0003-4819-75-1-140
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Published: Ann Intern Med. 1971;75(1):140-141.
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