ALFRED D. STEINBERG, M.D.; H. BENFER KALTREIDER, M.D.; PARKER J. STAPLES, M.D.; EDWARD J. GOETZL, M.D.; NORMAN TALAL, M.D.; JOHN L. DECKER, M.D., F.A.C.P.
Thirteen women with lupus nephritis were hospitalized for a 10-week double-blind therapeutic trial comparing oral cyclophosphamide with placebo. Concurrent corticosteroid therapy, up to 30 mg/day of prednisone, was permitted. Patients receiving cyclophosphamide had greater improvement than did placebo-treated patients in five indexes: anti-DNA antibodies, serum complement, urine sediment, proteinuria, and extrarenal disease. There was no difference in creatinine clearance. There was a strong positive correlation between cyclophosphamide dosage and number of indexes improved. Toxic side effects of cyclophosphamide were noted.
STEINBERG AD, KALTREIDER HB, STAPLES PJ, et al. Cyclophosphamide in Lupus Nephritis: A Controlled Trial. Ann Intern Med. 1971;75:165–171. doi: https://doi.org/10.7326/0003-4819-75-2-165
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Published: Ann Intern Med. 1971;75(2):165-171.
Autoimmune Kidney Disease, Lupus Erythematosus, Nephrology, Rheumatology.
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