JOHN R. MARSHALL, M.D.; ROBERT I. HENKIN, M.D.
Oocyte status and olfactory thresholds for three vapors were determined in 96 women with oligomenorrhea or amenorrhea and in 500 women with presumptively ovulatory menses. One percent of women with normal menses had type I hyposmia; 0.4% had type II. Both types I and II were present more frequently in patients with oocytes and menstrual abnormalities (P < 0.005). Type I was most frequently present in patients with primary amenorrhea and oocytes (20%). Type II was most frequently present in women with primary amenorrhea without oocytes (83%). Although type II appears to be associated with a loss of oocytes, loss of oocytes was not associated with the development of any specific olfactory abnormality. Determination of olfactory acuity by clinical history and threshold-testing provides important information about patients with menstrual abnormalities and can serve as a simple, predictive sign and as a guide to the clinical management of patients with primary amenorrhea.
MARSHALL JR, HENKIN RI. Olfactory Acuity, Menstrual Abnormalities, and Oocyte Status. Ann Intern Med. 1971;75:207–211. doi: 10.7326/0003-4819-75-2-207
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Published: Ann Intern Med. 1971;75(2):207-211.
DOI: 10.7326/0003-4819-75-2-207
Cardiology, Endocrine and Metabolism, Neurology, Pulmonary/Critical Care.
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