FRANCINE AUBRY, M.D.; YVES LAPIERRE, M.D.; CLÉMENT NOËL, M.D.; JEAN DAVIGNON, M.D., F.A.C.P.
A 60-year-old woman with angina pectoris, discrete planar and tuberous xanthomas, and diffuse yellow orange pigmentation of the palms had both hypercholesterolemia and hypertriglyceridemia. On paper electrophoresis her plasma lipoprotein pattern was indistinguishable from that of hyperbetalipoproteinemia (type II). Carbohydrate feeding elicited a type IV pattern. Ultracentrifugal analysis of the plasma showed an abnormal beta lipoprotein floating at density 1.006. This anomaly persisted after normalization of plasma lipids by the administration of ethyl 2-(p-chlorophenoxy)-2-methylpropionate. Investigation of the kindred and the absence of secondary causes to account for the hyperlipidemia were also consistent with the diagnosis of primary type III hyperlipoproteinemia. The criteria for diagnosis of type III hyperlipoproteinemia are reviewed and the danger of relying on the paper electrophoretic pattern alone is emphasized. The diagnosis of type III disease should not
be made until the presence of "floating" beta lipoprotein is demonstrated by ultracentrifugation.
AUBRY F, LAPIERRE Y, NOËL C, et al. Ultracentrifugal Demonstration of Floating Beta Lipoproteins in Type III Hyperlipoproteinemia: Diagnostic Value. Ann Intern Med. 1971;75:231–237. doi: https://doi.org/10.7326/0003-4819-75-2-231
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Published: Ann Intern Med. 1971;75(2):231-237.
Cardiology, Coronary Risk Factors, Dyslipidemia.
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